Endocrine Abstracts

Ovariectomy of immature female rats, results in significant decrease of trabecular bone volume and in cortical bone thickness. Previously we found that estradiol-17β (E2) restored bone structure of ovariectomized female rats (Ovx) to values obtained in intact sham-operated female rats. E2 also selectively stimulated creatine kinase specific activity (CK) a hormonal-genomic activity marker. In the present study, we compared the effects of E2</sub...

Oestradiol-17β regulates diverse tissues and cells, both within and outside the reproductive system including human cancer cells. Currently used ERs agonists or antagonists are synthetic compounds prepared by structure modifications. Alternatively, peptide mimics of steroids would allow preparation of biased combinatorial libraries of chemical and biological origin, from which estrogenic peptides with tissue selective profiles can be selected. The phage-display peptide li...

Vitamin D receptors are widely expressed in the skeletal system, and vitamin D and its metabolites and analogs, exert a variety of biological activities such as regulation of cellular proliferation and differentiation, cell calcium transients and energy metabolism in vitro. The latter is exerted through the control of the brain type isozyme of creatine kinase specific activity (CK), which serves to provide a readily available reservoir for ATP generation under increased worklo...